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04/28/2015 MoLife Research Seminar: Prof. Dr. Mark Helm

Tuesday, April 28, 2015 - 13:00
RNA modification
The recent surge in the field of naturally occurring nucleic acid modifications has been promoted by exciting discoveries e.g. of new chemically sophisticated structures, of mRNA methylation, and of mechanisms of oxidative demethylation. In addition to established structure/function studies in tRNAs it has become increasingly clear that modifications with important biological functions are present all over genomes and transcriptomes, but biologists lack the means for discovery and larger scale analytics. To address these shortcomings, we are establishing a combination of ultrasensitive detection by LC-MS/MS, chemical reagents for the selective conjugation to modified nucleosides, and deep sequencing techniques.   
Talk by:
Prof. Dr. Mark Helm 
Johannes Gutenberg-Universität Mainz 
Institut für Pharmazie und Biochemie  / Institute of Pharmacy and Biochemistry 
Raum 03-111/03-113 
Staudinger Weg 5 
D-55128 Mainz 
Deutschland / Germany
Fon 49-6131-3925731 
Fax 49-6131-3920373
Prof. Dr. Christian Hammann
Professor of Biochemistry
Life Sciences and Chemistry -  Focus area Health 
Building Research II, Room 119 / Campus Ring 6 / 28759 Bremen / Germany
Email:  c.hammann [at]
Tel: +49 421 200-3247 / Fax: +49 421 200-3249