RNA modification
The recent surge in the field of naturally occurring nucleic acid modifications has been promoted by exciting discoveries e.g. of new chemically sophisticated structures, of mRNA methylation, and of mechanisms of oxidative demethylation. In addition to established structure/function studies in tRNAs it has become increasingly clear that modifications with important biological functions are present all over genomes and transcriptomes, but biologists lack the means for discovery and larger scale analytics. To address these shortcomings, we are establishing a combination of ultrasensitive detection by LC-MS/MS, chemical reagents for the selective conjugation to modified nucleosides, and deep sequencing techniques.
Talk by:
Prof. Dr. Mark Helm
Johannes Gutenberg-Universität Mainz
Institut für Pharmazie und Biochemie / Institute of Pharmacy and Biochemistry
Raum 03-111/03-113
Staudinger Weg 5
D-55128 Mainz
Deutschland / Germany
Fon 49-6131-3925731
Fax 49-6131-3920373
E-mail: mhelmuni-mainz.de
Prof. Dr. Christian Hammann
Professor of Biochemistry
Life Sciences and Chemistry - Focus area Health
Building Research II, Room 119 / Campus Ring 6 / 28759 Bremen / Germany
Email: c.hammann [at] jacobs-university.de
Tel: +49 421 200-3247 / Fax: +49 421 200-3249
Link to Homepage: https://www.jacobs-university.de/ses/chammann/ribogenetics