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Prof. Dr. Klaudia Brix
Prof. Dr. Klaudia Brix
Prof. Dr.
Professor of Cell Biology
Life Sciences & Chemistry

Campus Ring 1 28759 Bremen Germany

+49 421 200-3249
k.brix [at]
Research II, Room 107
Research Interests: 
  • plant-derived bioactive substances
  • proteases of the thyroid gland
  • proteases of the gastro-intestinal tract
  • proteases of the CNS with importance for memory and learning
  • proteases important for cell migration during wound healing of the skin
  • proteases important for thyroid and colon cancer


University Education: 
Habilitation and Venia legendi in Cell Biology, Univ. Bonn, Germany
Dissertation (Dr. rer. nat.) in Biology, Univ. Bonn, Germany
Diploma in Biology, Univ. Bonn, Germany


Fellowships and Awards: 
“Lise-Meitner-Habilitationsstipendiatin”, Ministry of Science and Research
of Nordrhein-Westfalen, Germany
Scholarship Holder “Graduiertenförderung”, Ministry of Science and
Research of Nordrhein-Westfalen, Germany


2018Chair of Gordon Research Conference "Protein Processing, Trafficking, and Secretion", July 15-20, 2018, New London, NH, USA
2016Vice Chair of Gordon Research Conference “Protein Processing, Trafficking, and Secretion”, July 24-29, 2016, New London, NH, USA
since 2016Protoplasma, Review Editor Animal Cell Biology
2012Co-Coordinator of the SPP 1629 "THYROID TRANS ACT - Translation of Thyroid Hormone Actions beyond Classical Concepts"
2012Chair of Gordon Research Conference "Proteolytic Enzymes & Their Inhibitors", June 17-22, 2012, Il Ciocco, Lucca (Barga), Italy
Vice Chair of Gordon Research Conference "Proteolytic Enzymes & Their Inhibitors", May 2-7, 2010, Il Ciocco, Lucca (Barga), Italy
Vice-President of International Proteolysis Society
Council Member of International Proteolysis Society, Representative of Europe and Africa
Mentor Recognition Award, University of California San Diego, U.S.A.
since 2004
Editorial Board of European Journal of Cell Biology


Research and Teaching Positions: 
since 01/2006
Full Professor of Cell Biology, Jacobs University Bremen (formerly: IUB), Bremen, Germany
2010-2012Vice-Speaker of the Molecular Life Science Research Center, Jacobs University Bremen
Associate Professor of Cell Biology, Jacobs University Bremen, Bremen (then, IUB),
Assistant Professor (“Oberassistentin”) of Cell Biology (Univ. Bonn)
Acting Professor of Cell Biology and Vice-Chairperson (Univ. Bonn)
“Wissenschaftliche Assistentin” of Cell Biology (Univ. Bonn)
Research Scientist (Univ. Düsseldorf)
Research Scientist in the Focus Project “Cytoskeleton”, DFG (Univ. Bonn)
Teaching Experience
Fall 2002
Lectures and Practical Courses in the Undergraduate Major "BCCB - Biochemistry and Cell Biology", "MCCB - Medicinal Chemistry and Chemical Biology", and "MedNat - Medical Natural Sciences"; and BCCB Program Coordinator from Fall 2006 - Spring 2014 
Fall 2002
Supervision of PhD-Students; Co-Supervision of PhD-Students; Host of visiting Students from Denmark, Germany, Greece, Italy, Poland, Slovenia and Switzerland; external PhD-examiner for Universities in Africa, Australia and Europe; Supervision of MSc-Students
Independent Lecturer, Venia legendi in “Cell Biology”, Lectures, Practical Courses, Laboratory Courses, and Seminars for Students of Biology (Univ. Bonn)
Independent and Dependent Supervisor of Diploma and PhD Students (Univ. Bonn)
Lecturer in substitution of the responsible Professor (Univ. Bonn)
Teaching Associate in various Practical Courses (Univ. Bonn)


Funded Projects: 
  • DFG grant BR 1308/13-2 “Coordination of SPP 1629 THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts” – Priority Program; Führer, Brix, Biebermann. 2015 – 2018
  • DFG grant BR 1308/11-2 „Auto-regulation of the thyroid gland by classical and non-classical pathways“ in the framework of SPP 1629 THYROID TRANS ACT; PI: Klaudia Brix. 2015 – 2018




  • Proteases: Structure and Function, Klaudia Brix & Walter Stöcker (Eds.), Springer-Verlag Wien 2013., ISBN 978-3-7091-0884-0, ISBN 978-3-7091-0885-7 (eBook)., doi:10.1007/978-3-7091-0885-7. , Springer Wien, Heidelberg, New York, Dordrecht, London. Library of Congress Control Number: 2013956226.

Selection (Original Articles / Reviews):

  • Qatato, M. / J. Szumska, V. Skripnik, E. Rijntjes, J. Köhrle, and K. Brix (2018). Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression. Front. Pharmacol. 9:221. doi: 10.3389/fphar.2018.00221
  • Fischer, J., G. Kleinau, C. Rutz, D. Zwanziger, N. Khajavi, A. Müller, M. Rehders, K. Brix, C.L. Worth, D. Führer, H. Krude, B. Wiesner, R. Schülein / H. Biebermann (2017). Evidence of G-protein coupled receptor and substrate transporter heteromerization at a single molecule level. Cell. Mol. Life Sci.
  • Oettmeier, C., K. Brix, and H.-G. Döbereiner (2017). Topical Review: Physarum polycephalum – a new take on a classic model system. J. Phys. D: Appl. Phys. 50, no. 41.
  • Rakov, H., K. Engels, G.S. Hönes, K. Brix, J. Köhrle, L.C. Moeller, D. Zwanziger, D. Führer (2017). Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice. Biology of Sex Differences 8, 38. DOI 10.1186/s13293-017-0159-1.
  • Badziong, J., S. Ting, S. Synoracki, V. Tiedje, K. Brix, G. Brabant, L.C. Moeller, K.W. Schmid, D. Führer, D. Zwanziger (2017). Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism. Eur. J. Endocrinol. 177, 243-250. Doi:10.1530/EJE-17-0279
  • Said, I.H., A. Rezk, I. Hussain, A. Grimbs, A. Shrestha, H. Schepker, K. Brix, M.S. Ullrich, and N. Kuhnert (2017). Metabolome comparison of bioactive and inactive Rhododendron extracts and identification of an antibacterial cannabinoid(s) from Rhododendron collettianum. Phytochem. Anal. 28, 454–464. Doi:10.1002/pca.2694
  • Grimbs, A., A. Shrestha, A.S.D. Rezk, S. Grimbs, I. Hakeem Said, H. Schepker, M.-T. Hütt, D.C. Albach, K. Brix, N. Kuhnert, and M.S. Ullrich (2017). Bioactivity in Rhododendron: A systemic analysis of antimicrobial and cytotoxic activities and their phylogenetic and phytochemical origins. Frontiers in Plant Science, 8, Article 551. Doi: 10.3389/fpls.2017.00551
  • Couture, F., A.M. Jansen, P. Taghert, and K. Brix (2017). EJCB – Molecular basis of protein fates in the secretory and endocytic pathways, and beyond. Eur. J. Cell Biol. 96, 369–371. Doi:10.1016/j.ejcb.2017.06.006
  • Weber, J., J. McInnes, C. Kizilirmak, M. Rehders, M. Qatato, E.K. Wirth, U. Schweizer, F. Verrey, H. Heuer, and K. Brix (2017). Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland. Eur. J. Cell Biol. 96, 440-456. doi: 10.1016/j.ejcb.2017.02.002
  • Tamhane, T., R. Illukkumbura, S. Lu, G.M. Maelandsmo, M.H. Haugen, and K. Brix (2016). Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells. Biochimie 122, 208-218
  • Rezk, A., A. Al-Hashimi, W. John, H. Schepker, M.S. Ullrich, and K. Brix (2015b). Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells. BMC Complement Altern Med. 15:364
  • Szumska, J., M. Qatato, M. Rehders, D. Führer, H. Biebermann, D.K. Grandy, J. Köhrle, and K. Brix (2015). Trace amine-associated receptor 1 localization at the apical plasma membrane domain of Fisher rat thyroid epithelial cells is confined to cilia. Eur. Thyroid J. 4 (Suppl. 1), 30-41
  • Führer, D. / K. Brix / H. Biebermann (2015). Understanding the healthy thyroid state in 2015. Eur. Thyroid J. 4 (Suppl. 1), 1-8
  • Brix, K., J. McInnes, A. Al-Hashimi, M. Rehders, T. Tamhane, M.H. Haugen (2015). Proteolysis mediated by cysteine cathepsins and legumain - recent advances and cell biological challenges. Protoplasma 252, 755-774
  • Rezk, A., J. Nolzen, H. Schepker, D.C. Albach, K. Brix, and M.S. Ullrich (2015a). Phylogenetic spectrum and analysis of antibacterial activities of leaf extracts from plants of the genus Rhododendron. BMC Complementary & Alternative Medicine 15:67
  • Haugen, M.H., K. Boye, J.M. Nesland, S.J. Pettersen, E.V. Egeland, T. Tamhane, K. Brix, G.M. Maelandsmo, and K. Flatmark (2015).  High expression of the cysteine proteinase legumain in colorectal cancer - Implications for therapeutic targeting. Eur. J. Cancer 51, 9-17
  • Tamhane, T. / M. Arampatzidou, V. Gerganova, M. Tacke, R. Illukkumbura, S. Dauth, N. Schaschke, C. Peters, T. Reinheckel, and K. Brix (2014). The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol. Chem. 395, 1201-1219
  • Führer, D. / K. Brix / H. Biebermann (2014). Übersicht / Review article: Schilddrüsenhormonwirkung – jenseits klassischer Konzepte. Das Schwerpunktprogramm „THYROID TRANS ACT“ (SPP1629) der Deutschen Forschungsgemeinschaft. Thyroid hormone action beyond classical concepts. The priority programme „THYROID TRANS ACT“ (SPP1629) of the German Research Foundation. Dtsch. Med. Wochenschr. 139, 492-496
  • Haugen, M.H., H.T. Johansen, S.J. Pettersen, R. Solberg, K. Brix, K. Flatmark, and G.M. Maelandsmo (2013). Nuclear legumain activity in colorectal cancer. PLoS One 8(1), e52980
  • Brix, K., D. Führer, and H. Biebermann (2011). Molecules imprtant for thyroid hormone synthesis and action - known facts and future perspectives. Thyroid Research 4 (Suppl 1), S9
  • Dauth, S., R.F. Sirbulescu, S. Jordans, M. Rehders, L. Avena, J. Oswald, A. Lerchl, P. Saftig, and K. Brix (2011). Cathepsin K deficiency in mice induces structural and metabolic changes in the cenetral nervous system that are associated with learning and memory deficits. BMC Neuroscience 12, 74. 
  • Dauth, S., M. Arampatzidou, M. Rehders, D. M. T. Yu, D. Führer, and K. Brix (2011). Thyroid cathepsin K - roles in physiology and thyroid disease. Clin. Rev. Bone Miner. Metab. 9, 94-106.
  • Jordans, S., S. Jenko-Kokalj, N. M. Kühl, S. Tedelind, W. Sendt, D. Brömme, D. Turk, and K. Brix (2009). Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochemstry 10, 23. Highly Accessed.
  • Mayer, K., A. Vreemann, H. Qu, and K. Brix (2009). Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation. Biol. Chem. 390, 471-480.
  • Brix, K., A. Dunkhorst, K. Mayer, and S. Jordans (2008). Cysteine cathepsins: Cellular roadmap to different functions. Biochimie 90, 194-207
  • Büth, H., P.L. Buttigieg, R. Ostafe, M. Rehders, S.R. Dannenmann, N. Schaschke, H.-J. Stark, P. Boukamp, and K. Brix (2007). Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. Eur. J. Cell Biol. 86, 747-761
  • Brix, K., and S. Jordans (2005). News & Views: Watching proteases in action. Nature Chem. Biol. 1, 186-187.
  • Brix, K. (2005). Chapter 05: Lysosomal Proteases: Revival of the Sleeping Beauty. In: Lysosomes, edited by Paul Saftig, Landes Bioscience. REVIEW.
  • Friedrichs, B., C. Tepel, Th. Reinheckel, J. Deussing, K. von Figura, V. Herzog, Ch. Peters, P. Saftig, and K. Brix (2003). Thyroid functions of mouse cathepsins B, K, and L. J. Clin. Invest. 111, 1733-1745.
  • Linke, M., V. Herzog, and K. Brix (2002). Trafficking of lysosomal cathepsin B – green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. J. Cell Sci. 115, 4877-4889.
  • Brix, K., M. Linke, C. Tepel, and V. Herzog (2001). Cysteine proteinases mediate extracellular prohormone processing in the thyroid. Review. Biol. Chem. 382, 717-725.
  • Tepel, C., D. Brömme, V. Herzog, and K. Brix (2000). Cathepsin K in thyroid epithelial cells: Sequence, localization, and possible function in extracellular proteolysis of thyroglobulin. J. Cell Sci. 113, 4487-4498.
  • Brix, K., P. Lemansky, and V. Herzog (1996). Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells. Endocrinology 137, 1963-1974.
  • Brix, K., and V. Herzog (1994). Extrathyroidal release of thyroid hormones from thyroglobulin by J774 mouse macrophages. J. Clin. Invest. 93, 1388-1396.
  • Stockem, W., and K. Brix (1994). Analysis of microfilament organization and contractile activities in Physarum. Int. Rev. Cytol. 149, 145-215.


Other Professional Activities: 
Memberships in Scientific Societies
American Society for Cell Biology
DGEDeutsche Gesellschaft für Endokrinology; therein: Sektion Schilddrüse
German Society for Cell Biology
European Society for Endocrinology
European Thyroid Association
International Proteolysis Society
New York Academy of Sciences
Academic Committees and Responsibilities
since 2003
Scientific Head and Coordinator of the Reference Center for Confocal Laser Scanning Microscopy at Jacobs University Bremen
since 2002
Biological Safety Officer, Radiation Safety Officer, Jacobs University Bremen (formerly IUB)
2005-2012Committee Member of International Center for Transdisciplinary Studies ICTS at Jacobs University Bremen
2004-2014Member of the Graduate Admissions Committee "MoLife"
Organiser of the Molecular Life Sciences Seminar, School of Engineering and Science, IUB
Member of the Steering Committee, Faculty Club e.V., IUB, now University Club e.V. at Jacobs University Bremen
Member of the Academic Integrity Committee, International University Bremen
Member of the Committee for Biological Safety Regulations, Univ. Bonn
Member of the Advisory Board of the Representative for Equal Opportunity, Univ. Bonn
Committee Member of the Division of Biology, Member of the Faculty of Mathematics and Life Sciences, Vice Chairperson of the Institute of Cell Biology, Univ. Bonn
Representative of the Scientific Fellows of the Institute of Cell Biology, Univ. Bonn